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BRAF Mutations in Colorectal Cancer: Clinical Relevance and Role in Targeted Therapy

1 Nov 2012

Abstract excerpt

Experts have long appreciated that the clinical entity we call colorectal cancer is a phenotype made up of numerous different genotypes, accounting for the wide variation in clinical course and responses to therapies experienced by different individuals. Observations reported by Khambata-Ford et al 1 and subsequently confirmed by Amado et al 2 have made the practicing community aware that activating mutations in...

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PMID: 23138171
DOI: 10.6004/jnccn.2012.0148

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