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Article

Integrative normalization and comparative analysis for metabolic fingerprinting by comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry.

Analytical chemistry - 15 Jul 2009

Almstetter Martin F, Appel Inka J, Gruber Michael A, Lottaz Claudio, Timischl Birgit, Spang Rainer, Dettmer Katja, Oefner Peter J

Abstract excerpt

Comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry (GC x GC-TOF-MS) was applied to the comparative metabolic fingerprinting of a wild-type versus a double mutant strain of Escherichia coli lacking the transhydrogenases UdhA and PntAB. Using peak lists generated with the Leco ChromaTOF software as input, we developed retention time correction and data alignment tools (INCA). The...

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PMID: 19522528
DOI: 10.1021/ac900528b

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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