Article
Genotyping of Mycobacterium tuberculosis clinical isolates using IS6110-based restriction fragment length polymorphism analysis.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2009
Bifani Pablo, Kurepina Natalia, Mathema Barun, Wang Xiao-Ming, Kreiswirth Barry
Abstract excerpt
A number of phylogenetic studies of Mycobacterium tuberculosis have suggested a highly clonal population structure. Despite the extreme homogeneity of M. tuberculosis strains, the genome is punctuated by a number of polymorphic regions that give rise to sufficient diversity, thus forming the basis for molecular epidemiologic studies of tuberculosis. As such, insertion sequence (IS) 6110, which is unique to...
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