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Article

Differential activation of acid sphingomyelinase and ceramide release determines invasiveness of Neisseria meningitidis into brain endothelial cells.

PLoS pathogens - 1 Jun 2014

Simonis Alexander, Hebling Sabrina, Gulbins Erich, Schneider-Schaulies Sibylle, Schubert-Unkmeir Alexandra

Abstract excerpt

The interaction with brain endothelial cells is central to the pathogenicity of Neisseria meningitidis infections. Here, we show that N. meningitidis causes transient activation of acid sphingomyelinase (ASM) followed by ceramide release in brain endothelial cells. In response to N. meningitidis infection, ASM and ceramide are displayed at the outer leaflet of the cell membrane and condense into large membrane...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24945304
DOI: 10.1371/journal.ppat.1004160
PMCID: PMC4055770

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