Article
Dicer-regulated microRNAs 222 and 339 promote resistance of cancer cells to cytotoxic T-lymphocytes by down-regulation of ICAM-1.
Proceedings of the National Academy of Sciences of the United States of America - 30 Jun 2009
Ueda Ryo, Kohanbash Gary, Sasaki Kotaro, Fujita Mitsugu, Zhu Xinmei, Kastenhuber Edward R, McDonald Heather A, Potter Douglas M, Hamilton Ronald L, Lotze Michael T, Khan Saleem A, Sobol Robert W, Okada Hideho
Abstract excerpt
The RNase III endonuclease Dicer plays a key role in generation of microRNAs (miRs). We hypothesized that Dicer regulates cancer cell susceptibility to immune surveillance through miR processing. Indeed, Dicer disruption up-regulated intercellular cell adhesion molecule (ICAM)-1 and enhanced the susceptibility of tumor cells to antigen-specific lysis by cytotoxic T-lymphocytes (CTLs), while expression of other...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.