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Minireview: Epigenetic Alterations in Human Prostate Cancers

11 Jun 2009

Abstract excerpt

Human prostate cancer cells carry a myriad of genome defects, including both genetic and epigenetic alterations. These changes, which can be maintained through mitosis, generate malignant phenotypes capable of selective growth, survival, invasion, and metastasis. During prostatic carcinogenesis, epigenetic changes arise earlier than genetic defects, linking the appearance of epigenetic alterations in some way to...

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PMID: 19520778
DOI: 10.1210/en.2009-0573

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