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Article

Drug consumption in medication overuse headache is influenced by brain-derived neurotrophic factor Val66Met polymorphism.

The journal of headache and pain - 1 Oct 2009

Di Lorenzo Cherubino, Di Lorenzo Giorgio, Sances Grazia, Ghiotto Natascia, Guaschino Elena, Grieco Gaetano S, Santorelli Filippo M, Casali Carlo, Troisi Alfonso, Siracusano Alberto, Pierelli Francesco

Abstract excerpt

Medication overuse headache (MOH) can be considered a clinical condition at the boundaries between drug addiction and chronic pain disorder. The common 196G > A single-nucleotide polymorphism of BDNF gene, resulting in a valine 66 to methionine (Val66Met), is related with behaviour disorders and substance abuse. With the aim of identifying a worsening factor in MOH, rather than the detection of a specific risk...

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Identifiers

PMID: 19517061
DOI: 10.1007/s10194-009-0136-0
PMCID: PMC3452090

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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