Article
Mechanisms associated with HIV-1 resistance to acyclovir by the V75I mutation in reverse transcriptase.
The Journal of biological chemistry - 7 Aug 2009
Tchesnokov Egor P, Obikhod Aleksandr, Massud Ivana, Lisco Andrea, Vanpouille Christophe, Brichacek Beda, Balzarini Jan, McGuigan Christopher, Derudas Marco, Margolis Leonid, Schinazi Raymond F, Götte Matthias
Abstract excerpt
It has recently been demonstrated that the anti-herpetic drug acyclovir (ACV) also displays antiviral activity against the human immunodeficiency virus type 1 (HIV-1). The triphosphate form of ACV is accepted by HIV-1 reverse transcriptase (RT), and subsequent incorporation leads to classical chain termination. Like all approved nucleoside analogue RT inhibitors (NRTIs), the selective pressure of ACV is...
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