Article
E3 Ubiquitin Ligase Cbl-b Prevents Tumor Metastasis by Maintaining the Epithelial Phenotype in Multiple Drug-Resistant Gastric and Breast Cancer Cells.
Neoplasia (New York, N.Y.) - 1 Apr 2017
Xu Ling, Zhang Ye, Qu Xiujuan, Che Xiaofang, Guo Tianshu, Cai Ying, Li Aodi, Li Danni, Li Ce, Wen Ti, Fan Yibo, Hou Kezuo, Ma Yanju, Hu Xuejun, Liu Yunpeng
Abstract excerpt
Multiple drug resistance (MDR) and metastasis are two major factors that contribute to the failure of cancer treatment. However, the relationship between MDR and metastasis has not been characterized. Additionally, the role of the E3 ubiquitin ligase Cbl-b in metastasis of MDR gastric and breast cancer is not well known. In the present study, we found that MDR gastric and breast cancer cells possess a typical...
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