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Article

No evidence for association between the renin-angiotensin-aldosterone system and otosclerosis in a large Belgian-Dutch population.

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology - 1 Dec 2009

Schrauwen Isabelle, Thys Melissa, Vanderstraeten Kathleen, Fransen Erik, Ealy Megan, Cremers Cor W R J, Dhooge Ingeborg, Van de Heyning Paul, Offeciers Erwin, Smith Richard J H, Van Camp Guy

Abstract excerpt

HYPOTHESIS/BACKGROUND: Otosclerosis is a frequent cause of hearing impairment in the Caucasian population and is characterized by abnormal bone remodeling of the otic capsule. Associations with several genes have been reported, and recently, an association between the renin-angiotensin-aldosteron...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Data Interpretation, Statistical

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Share to Peptidyl-Dipeptidase A

Share to Receptor, Angiotensin, Type 1

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Source

Identifiers

PMID: 19503013
DOI: 10.1097/MAO.0b013e3181ab3058

Genes

ACE
AGT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19503013-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

No evidence for association between the renin-angiotensin-aldosterone system and otosclerosis in a large Belgian-Dutch population.PMID 19503013Read ↗

Relation between renin-angiotensin-aldosterone system and otosclerosis: a genetic association and in vitro study.Semantic proximity Read ↗

<i>COL1A1</i> association and otosclerosis: A meta‐analysisSemantic proximity Read ↗

Clinical and genetic analysis of two Tunisian otosclerosis families.Semantic proximity Read ↗

No evidence for the expression of renin-angiotensin-aldosterone system in otosclerotic stapes footplates.Semantic proximity Read ↗

Association of bone morphogenetic proteins with otosclerosis.Semantic proximity Read ↗

Genetic variants in the RELN gene are associated with otosclerosis in multiple European populations.Semantic proximity Read ↗

The coding polymorphism T263I in TGF-beta1 is associated with otosclerosis in two independent populations.Semantic proximity Read ↗

Association of COL1A1 and TGFB1 polymorphisms with otosclerosis in a Tunisian population.Semantic proximity Read ↗

Genetic association analysis in a clinically and histologically confirmed otosclerosis population confirms association with the TGFB1 gene but suggests an association of the RELN gene with a clinically indistinguishable otosclerosis-like phenotype.Semantic proximity Read ↗

Proposed association between the COL1A1 and COL1A2 genes and otosclerosis is not supported by a case-control study in Spain.Semantic proximity Read ↗

The rs39335 polymorphism of the RELN gene is not associated with otosclerosis in a southern Italian population.Semantic proximity Read ↗

Association of COL1A1 polymorphism in Turkish patients with otosclerosis.Semantic proximity Read ↗

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