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Article

Association of bone morphogenetic proteins with otosclerosis.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Apr 2008

Schrauwen Isabelle, Thys Melissa, Vanderstraeten Kathleen, Fransen Erik, Dieltjens Nele, Huyghe Jeroen R, Ealy Megan, Claustres Mireille, Cremers Cor R W J, Dhooge Ingeborg, Declau Frank, Van de Heyning Paul, Vincent Robert, Somers Thomas, Offeciers Erwin, Smith Richard J H, Van Camp Guy

Abstract excerpt

UNLABELLED: We studied the role of polymorphisms in 13 candidate genes on the risk of otosclerosis in two large independent case-control sets. We found significant association in both populations with BMP2 and BMP4, implicating these two genes in the pathogenesis of this disease. INTRODUCTION: Otosclerosis is a progressive disorder of the human temporal bone that leads to conductive hearing loss and in some cases...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18021008
DOI: 10.1359/jbmr.071112
PMCID: PMC2669162

Genes

BMP2
BMP4
TGFB1

Variants

rs17563

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Association of bone morphogenetic proteins with otosclerosis.PMID 18021008Read ↗

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