Article
Globin chain analysis: an important tool in phenotype study of hemoglobin disorders.
Clinical biochemistry - 1 Dec 2009
Wajcman Henri, Riou Jean
Abstract excerpt
Phenotype studies still occupy a key position in the diagnosis of hemoglobin (Hb) disorders. An additional dimension to the methods for diagnosis of Hb disorders which are mostly based on difference in charge of the Hb molecules may be brought by studying some properties of the globin chains. Among the methods proposed, reversed-phase liquid-chromatography (RP-LC) reveals differences in hydrophobicity allowing to...
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