Article
Detection of a thalassemic alpha-chain variant (Hemoglobin Groene Hart) by reversed-phase liquid chromatography.
Clinical chemistry - 1 Jun 2008
Zanella-Cleon Isabelle, Becchi Michel, Lacan Philippe, Giordano Piero C, Wajcman Henri, Francina Alain
Abstract excerpt
BACKGROUND: Hemoglobin (Hb) Groene Hart [alpha119 (H2)Pro-->Ser (alpha1)], also known as Hb Bernalda, is a nondeletional alpha-thalassemic Hb variant that is frequent in southern Italy and North Africa. This variant is not supposed to be produced in the erythrocytes of carriers. The alpha-thalass...
Topics
- Adult
- Child, Preschool
- Chromatography, Liquid
- Hemoglobins, Abnormal
- Humans
- Models, Molecular
- Mutation
- Spectrometry, Mass, Electrospray Ionization
- Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
- Tandem Mass Spectrometry
- Thalassemia