Separation of adult chains of abnormal haemoglobin: Identification by reversed-phase high-performance liquid chromatography.

doi:10.1002/jcla.20007

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Article

Separation of adult chains of abnormal haemoglobin: Identification by reversed-phase high-performance liquid chromatography.

Journal of clinical laboratory analysis - 1 Jan 2004

Yapo Paul Angoué, Datté Jacques Y, Yapo Ayekoé, Wachman Henri

Abstract excerpt

Rare abnormal haemoglobin (Hb) often poses a problem in the diagnosis of relative electrophoresis mobility. The rare neutral Hbs interact with the Hb S and thus can increase the severity of sickle cell anaemia. In the present study, we investigated the use of reversed-phase high-performance liquid chromatography (RP-HPLC) as a method for the identification of neutral or unstable Hb, and compared it with the...

Topics

Adult
Chromatography, High Pressure Liquid
Electrophoresis
Hemoglobins, Abnormal
Humans
Isoelectric Focusing
Mutation

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Identifiers

PMID: 15065210
DOI: 10.1002/jcla.20007
PMCID: PMC6807734

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