Chaperone client proteins evolve slower than non-client proteins.

Abstract excerpt

Chaperones are important molecular machinery that assists proteins to attain their native three-dimensional structure crucial for function. Earlier studies using experimental evolution showed that chaperones impose a relaxation of sequence constraints on their "client" proteins, which may lead to the fixation of slightly deleterious mutations on the latter. However, we hypothesized that such a phenomenon might be...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Protein Folding
• Share to Protein Interaction Mapping
• Share to Thermus