Article
Significantly altered systemic exposure to atorvastatin acid following gastric bypass surgery in morbidly obese patients.
Clinical pharmacology and therapeutics - 1 Sept 2009
Skottheim I B, Stormark K, Christensen H, Jakobsen G S, Hjelmesaeth J, Jenssen T, Reubsaet J L E, Sandbu R, Asberg A
Abstract excerpt
The impact of gastric bypass on atorvastatin pharmacokinetics was investigated in 12 morbidly obese patients being treated with 20-80 mg atorvastatin each morning. Eight-hour pharmacokinetic investigations were performed the day before the surgery and at a median of 5 weeks (range 3-6 weeks) after the surgery. Gastric bypass surgery produced a variable effect on individual systemic exposure to atorvastatin acid...
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