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Alternative Reassortment Events Leading to Transmissible H9N1 Influenza Viruses in the Ferret Model

17 Oct 2013

Abstract excerpt

Influenza A H9N2 viruses are common poultry pathogens that occasionally infect swine and humans. It has been shown previously with H9N2 viruses that reassortment can generate novel viruses with increased transmissibility. Here, we demonstrate the modeling power of a novel transfection-based inoculation system to select reassortant viruses under in vivo selective pressure. Plasmids containing the genes from an...

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PMID: 24131710
DOI: 10.1128/jvi.02677-13

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