Article
Analysis of the prodynorphin promoter polymorphism in atopic dermatitis and disease-related pruritus.
Clinical and experimental dermatology - 1 Aug 2009
Greisenegger E K, Zimprich A, Zimprich F, Stingl G, Kopp T
Abstract excerpt
Pruritus is one of the key symptoms in atopic dermatitis (AD). The prodynorphin polypeptide is a precursor protein of pruritus-modulating opioid peptides. It is encoded by the prodynorphin gene (PDYN). To investigate a possible correlation of PDYN promoter polymorphisms with intensity of pruritus in patients with AD, we genotyped 211 Austrian patients with AD and 197 nonatopic controls. No significant association...
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