Article
Induction of HoxB transcription by retinoic acid requires actin polymerization.
Molecular biology of the cell - 1 Aug 2009
Ferrai Carmelo, Naum-Onganía Gabriela, Longobardi Elena, Palazzolo Martina, Disanza Andrea, Diaz Victor M, Crippa Massimo P, Scita Giorgio, Blasi Francesco
Abstract excerpt
We have analyzed the role of actin polymerization in retinoic acid (RA)-induced HoxB transcription, which is mediated by the HoxB regulator Prep1. RA induction of the HoxB genes can be prevented by the inhibition of actin polymerization. Importantly, inhibition of actin polymerization specifically affects the transcription of inducible Hox genes, but not that of their transcriptional regulators, the RARs, nor of...
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