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Article

The disruption of Sox21-mediated hair shaft cuticle differentiation causes cyclic alopecia in mice

26 May 2009

Abstract excerpt

Hair is maintained through a cyclic process that includes periodic regeneration of hair follicles in a stem cell-dependent manner. Little is known, however, about the cellular and molecular mechanisms that regulate the layered differentiation of the hair follicle. We have established a mutant mouse with a cyclic alopecia phenotype resulting from the targeted disruption of Sox21, a gene that encodes a HMG-box...

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PMID: 19470461
DOI: 10.1073/pnas.0808324106

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