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Article

'Cyclic alopecia' in Msx2 mutants: defects in hair cycling and hair shaft differentiation.

Development (Cambridge, England) - 1 Jan 2003

Ma Liang, Liu Jian, Wu Tobey, Plikus Maksim, Jiang Ting-Xin, Bi Qun, Liu Yi-Hsin, Müller-Röver Sven, Peters Heiko, Sundberg John P, Maxson Rob, Maas Richard L, Chuong Cheng-Ming

Abstract excerpt

Msx2-deficient mice exhibit progressive hair loss, starting at P14 and followed by successive cycles of wavelike regrowth and loss. During the hair cycle, Msx2 deficiency shortens anagen phase, but prolongs catagen and telogen. Msx2-deficient hair shafts are structurally abnormal. Molecular analyses suggest a Bmp4/Bmp2/Msx2/Foxn1 acidic hair keratin pathway is involved. These structurally abnormal hairs are...

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Source

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Identifiers

PMID: 12466204
DOI: 10.1242/dev.00201
PMCID: PMC4386654

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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