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Article

Cholesterol regulates melanogenesis in human epidermal melanocytes and melanoma cells

12 Mar 2009

Abstract excerpt

Cholesterol is important for membrane stability and is the key substrate for the synthesis of steroid hormones and vitamin D. Furthermore, it is a major component of the lipid barrier in the stratum corneum of the human epidermis. Considering that steroid hormone synthesis is taking place in epidermal melanocytes, we tested whether downstream oestrogen receptor/cAMP signalling via MITF/tyrosine...

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PMID: 19469904
DOI: 10.1111/j.1600-0625.2009.00850.x

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