Article
The immunobiology of primary sclerosing cholangitis.
Seminars in immunopathology - 1 Sept 2009
Aron Jonathan H, Bowlus Christopher L
Abstract excerpt
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease histologically characterized by the presence of intrahepatic and/or extrahepatic biliary duct concentric, obliterative fibrosis, eventually leading to cirrhosis. Approximately 75% of patients with PSC have inflammatory bowel disease. The male predominance of PSC, the lack of a defined, pathogenic autoantigen, and the potential role of the...
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