Article
Linkage analysis of adult height in a large pedigree from a Dutch genetically isolated population.
Human genetics - 1 Sept 2009
Axenovich Tatiana I, Zorkoltseva I V, Belonogova N M, Struchalin M V, Kirichenko A V, Kayser M, Oostra B A, van Duijn C M, Aulchenko Y S
Abstract excerpt
Despite extensive research of genetic determinants of human adult height, the genes identified up until now allow to predict only a small proportion of the trait's variance. To identify new genes we analyzed 2,486 genotyped and phenotyped individuals in a large pedigree including 23,612 members in 18 generations. The pedigree was derived from a young genetically isolated Dutch population, where genetic...
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