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Article

Comparative analysis of the sequences and structures of HIV-1 and HIV-2 proteases.

Proteins - 1 Jan 1991

Gustchina A, Weber I T

Abstract excerpt

The different isolates available for HIV-1 and HIV-2 were compared for the region of the protease (PR) sequence, and the variations in amino acids were analyzed with respect to the crystal structure of HIV-1 PR with inhibitor. Based on the extensive homology (39 identical out of 99 residues), models were built of the HIV-2 PR complexed with two different aspartic protease inhibitors, acetylpepstatin and a renin...

Topics

Amino Acid Sequence
Binding Sites
Crystallization
Electrochemistry
Genetic Variation
HIV Protease
HIV-1
HIV-2
Models, Molecular
Molecular Sequence Data
Molecular Structure
Protein Conformation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sequence Homology, Nucleic Acid

Source

Identifiers

PMID: 1946342
DOI: 10.1002/prot.340100406

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1946342-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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