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Article

Immune-deficient Drosophila melanogaster: a model for the innate immune response to human fungal pathogens.

Journal of immunology (Baltimore, Md. : 1950) - 1 May 2004

Alarco Anne-Marie, Marcil Anne, Chen Jian, Suter Beat, Thomas David, Whiteway Malcolm

Abstract excerpt

We explored the host-pathogen interactions of the human opportunistic fungus Candida albicans using Drosophila melanogaster. We established that a Drosophila strain devoid of functional Toll receptor is highly susceptible to the human pathogen C. albicans. Using this sensitive strain, we have been able to show that a set of specific C. albicans mutants of different virulence in mammalian infection models are also...

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Source

Identifiers

PMID: 15100306
DOI: 10.4049/jimmunol.172.9.5622

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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