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Article

A functional polymorphism in the reduced folate carrier gene and DNA hypomethylation in mothers of children with autism.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Sept 2010

James S Jill, Melnyk Stepan, Jernigan Stefanie, Pavliv Oleksandra, Trusty Timothy, Lehman Sara, Seidel Lisa, Gaylor David W, Cleves Mario A

Abstract excerpt

The biologic basis of autism is complex and is thought to involve multiple and variable gene-environment interactions. While the logical focus has been on the affected child, the impact of maternal genetics on intrauterine microenvironment during pivotal developmental windows could be substantial. Folate-dependent one carbon metabolism is a highly polymorphic pathway that regulates the distribution of one-carbon...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20468076
DOI: 10.1002/ajmg.b.31094
PMCID: PMC2943349

Genes

RFC1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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