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Article

Primary bovine intervertebral disc cells transduced with adenovirus overexpressing 12 BMPs and Sox9 maintain appropriate phenotype.

American journal of physical medicine & rehabilitation - 1 Jun 2009

Zhang Yejia, Markova Dessislava, Im Hee-Jeong, Hu Wenyang, Thonar Eugene J-M A, He Tong-Chuan, An Howard S, Phillips Frank M, Anderson D Greg

Abstract excerpt

OBJECTIVE: To confirm that primary intervertebral disc cells cultured in monolayer transduced with adenovirus maintained their phenotype, hence is an appropriate system to test gene therapy agents. DESIGN: Adult bovine nucleus pulposus and anulus fibrosus cells cultured in monolayer were transduced with adenoviruses expressing human bone morphogenetic proteins (AdBMPs) or Sox9 (AdSox9), or green fluorescence...

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Source

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Identifiers

PMID: 19454853
DOI: 10.1097/PHM.0b013e3181a5f0aa
PMCID: PMC2894691

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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