Article
Relative abundance of selenoprotein P isoforms in human plasma depends on genotype, se intake, and cancer status.
Antioxidants & redox signaling - 1 Nov 2009
Méplan Catherine, Nicol Fergus, Burtle Brian T, Crosley Lynne K, Arthur John R, Mathers John C, Hesketh John E
Abstract excerpt
Selenium (Se), a dietary trace metal essential for human health, is incorporated into selenoproteins as selenocysteine. Selenoprotein P (SePP), the major plasma selenoprotein, has both transport and antioxidant functions. In humans, it exists in plasma as two isoforms of approximately 50 and 60 kDa. This study investigated the effect of polymorphisms in the SEPP-1 gene, Se supplementation, and disease status on...
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