Article
Genetic polymorphisms in the human selenoprotein P gene determine the response of selenoprotein markers to selenium supplementation in a gender-specific manner (the SELGEN study).
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Oct 2007
Méplan Catherine, Crosley Lynne K, Nicol Fergus, Beckett Geoffrey J, Howie Alexander F, Hill Kristina E, Horgan Graham, Mathers John C, Arthur John R, Hesketh John E
Abstract excerpt
Selenium (Se), a micronutrient essential for human health, is incorporated into at least 25 selenoproteins including selenoprotein P (SePP), which transports Se within the body. This research identified two single nucleotide polymorphisms (SNPs) in the SePP gene, one in the coding region (position 24731, causing an Ala to Thr change) and one in the 3'untranslated region (position 25191). Their frequency was...
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