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Article

Selection of heterogeneous vancomycin-intermediate Staphylococcus aureus by imipenem.

Antimicrobial agents and chemotherapy - 1 Aug 2009

Katayama Yuki, Murakami-Kuroda Hiroko, Cui Longzhu, Hiramatsu Keiichi

Abstract excerpt

Vancomycin (VAN)-intermediate Staphylococcus aureus (VISA) and heterogeneous VISA (hVISA) isolates are considered to have emerged from VAN-susceptible S. aureus (VSSA) by spontaneous mutation during VAN exposure. We previously reported that laboratory mutant H14, obtained from VSSA strain Delta IP by exposure to imipenem (IPM), showed overexpression of the vraSR two-component system and a typical hVISA phenotype....

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Identifiers

PMID: 19451283
DOI: 10.1128/AAC.00834-08
PMCID: PMC2715608

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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