<i>Staphylococcus aureus</i> with Heterogeneous Resistance to Vancomycin: Epidemiology, Clinical Significance, and Critical Assessment of Diagnostic Methods

Abstract excerpt

The first report of Staphylococcus aureus with intermediate-level resistance to vancomycin (VISA) was from Japan in 1997 (20), raising the threat of incurable staphylococcal infections. Since then, a number of cases have been reported worldwide, with eight confirmed cases in the United States as of June 2002 (9, 13). The majority of these cases have occurred in patients who have had prolonged exposure to...

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