Article
c-Myc activates multiple metabolic networks to generate substrates for cell-cycle entry.
Oncogene - 9 Jul 2009
Morrish F, Isern N, Sadilek M, Jeffrey M, Hockenbery D M
Abstract excerpt
Cell proliferation requires the coordinated activity of cytosolic and mitochondrial metabolic pathways to provide ATP and building blocks for DNA, RNA and protein synthesis. Many metabolic pathway genes are targets of the c-myc oncogene and cell-cycle regulator. However, the contribution of c-Myc to the activation of cytosolic and mitochondrial metabolic networks during cell-cycle entry is unknown. Here, we...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.