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Article

AIRE Functions As an E3 Ubiquitin Ligase

19 Jan 2004

Abstract excerpt

Autoimmune regulator (AIRE) gene mutation is responsible for the development of autoimmune-polyendocrinopathy-candidiasis ectodermal dystrophy, an organ-specific autoimmune disease with monogenic autosomal recessive inheritance. AIRE is predominantly expressed in medullary epithelial cells of the thymus and is considered to play important roles in the establishment of self-tolerance. AIRE contains two plant...

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PMID: 14734522
DOI: 10.1084/jem.20031291

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