Article
Preclinical diagnosis of familial hypertrophic cardiomyopathy by genetic analysis of blood lymphocytes.
The New England journal of medicine - 19 Dec 1991
Rosenzweig A, Watkins H, Hwang D S, Miri M, McKenna W, Traill T A, Seidman J G, Seidman C E
Abstract excerpt
BACKGROUND: The clinical diagnosis of familial hypertrophic cardiomyopathy is usually made on the basis of the physical examination, electrocardiogram, and echocardiogram. Making an accurate diagnosis can be particularly difficult in children, who may not have cardiac hypertrophy until adulthood. Recently, we demonstrated that mutations in the cardiac myosin heavy-chain genes cause familial hypertrophic...
Topics
- Adolescent
- Adult
- Base Sequence
- Cardiomyopathy, Hypertrophic
- Child
- Child, Preschool
- Female
- Humans
- Lymphocytes
- Male
- Molecular Sequence Data