Article
Catalytically impaired hMYH and NEIL1 mutant proteins identified in patients with primary sclerosing cholangitis and cholangiocarcinoma.
Carcinogenesis - 1 Jul 2009
Forsbring Monika, Vik Erik S, Dalhus Bjørn, Karlsen Tom H, Bergquist Annika, Schrumpf Erik, Bjørås Magnar, Boberg Kirsten M, Alseth Ingrun
Abstract excerpt
The human hMYH and NEIL1 genes encode DNA glycosylases involved in repair of oxidative base damage and mutations in these genes are associated with certain cancers. Primary sclerosing cholangitis (PSC), a chronic cholestatic liver disease characterized by inflammatory destruction of the biliary tree, is often complicated by the development of cholangiocarcinoma (CCA). Here, we aimed to investigate the influence...
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