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Article

Chemical genetics and drug discovery in Xenopus.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2012

Tomlinson Matthew L, Hendry Adam E, Wheeler Grant N

Abstract excerpt

Chemical genetics uses small molecules to modulate protein function and has the potential to perturb any biochemical event in a complex cellular context. The application of chemical genetics to dissect biological processes has become an attractive alternative to mutagenesis screens due to its technical simplicity, inexpensive reagents, and low-startup costs. Xenopus embryos are particularly amenable to whole...

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PMID: 22956087
DOI: 10.1007/978-1-61779-992-1_9

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