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Article

Tunisian hereditary spastic paraplegias: clinical variability supported by genetic heterogeneity.

Clinical genetics - 1 Jun 2009

Boukhris A, Stevanin G, Feki I, Denora P, Elleuch N, Miladi M I, Goizet C, Truchetto J, Belal S, Brice A, Mhiri C

Abstract excerpt

Hereditary spastic paraplegias (HSP) constitute a clinically and genetically heterogeneous group of neurodegenerative disorders characterized by slowly progressive spasticity of the lower extremities. We performed the first clinical, epidemiological and genetic study of HSP in Southern Tunisia. We investigated 88 patients belonging to 38 unrelated Tunisian HSP families. We could establish the minimal prevalence...

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Source

Identifiers

PMID: 19438933
DOI: 10.1111/j.1399-0004.2009.01176.x

Genes

SPG11

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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