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Article

A link between the interleukin‐6/Stat3 anti‐apoptotic pathway and microRNA‐21 in preimplantation mouse embryos

12 May 2009

Abstract excerpt

Signal transducers and activators of transcription-3 (Stat3) plays a central role in interleukin-6 (IL-6)-mediated cell proliferation by inhibiting apoptosis in a variety of cell types. MicroRNA-21 (miRNA-21), a ubiquitous miRNA, acts as an anti-apoptotic factor that seems to be indirectly but strictly linked to Stat3. In order to determine whether the IL-6 induced Stat3 anti-apoptosis pathway is linked with...

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PMID: 19437447
DOI: 10.1002/mrd.21048

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