Article
Ginkgolide B induces apoptosis and developmental injury in mouse embryonic stem cells and blastocysts
27 Jul 2006
Abstract excerpt
BACKGROUND: Ginkgolide B, the major active component of Ginkgo biloba extracts, can both stimulate and inhibit apoptotic signalling. We previously showed that ginkgolide treatment of mouse blastocysts induces apoptosis, decreases cell numbers, retards early post-implantation blastocyst development and increases early-stage blastocyst death. Here, we report more detailed examinations of the cytotoxic effects of...
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