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Article

Activator protein-1 has an essential role in pancreatic cancer cells and is regulated by a novel Akt-mediated mechanism.

Molecular cancer research : MCR - 1 May 2009

Shin Sonyo, Asano Takayuki, Yao Yixin, Zhang Ronghua, Claret Francois-Xavier, Korc Murray, Sabapathy Kanaga, Menter David G, Abbruzzese James L, Reddy Shrikanth A G

Abstract excerpt

Activator protein-1 (AP-1) regulates the expression of several genes involved in human tumorigenesis. However, there is little known about this transcription factor in pancreatic ductal adenocarcinoma. We recently found high levels of AP-1-binding activities and multiple AP-1/DNA complexes containing c-Jun, JunD, Fra1, and Fra2 in pancreatic cancer cells. Transient transfection assays indicated that AP-1 was...

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Identifiers

PMID: 19435822
DOI: 10.1158/1541-7786.MCR-08-0462
PMCID: PMC4854281

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Activator protein-1 has an essential role in pancreatic cancer cells and is regulated by a novel Akt-mediated mechanism.PMID 19435822Read ↗

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