Article
A novel mutation in a patient with a deficiency of the eighth component of complement associated with recurrent meningococcal meningitis.
Journal of clinical immunology - 1 Sept 2009
Arnold D F, Roberts A G, Thomas A, Ferry B, Morgan B P, Chapel H
Abstract excerpt
INTRODUCTION: Complement component C8 is one of the five terminal complement components required for the formation of the membrane attack complex. Complete absence of C8 results in increased susceptibility to gram-negative bacteria such as Neisseria species. MATERIALS AND METHODS: Two functionally distinct C8 deficiency states have been described: C8 alpha-gamma deficiency has been predominantly reported amongst...
Topics
- Adolescent
- Antibiotic Prophylaxis
- Codon, Nonsense
- Complement C8
- Cytotoxicity, Immunologic
- DNA Mutational Analysis
- Genetic Predisposition to Disease
- Haemophilus Vaccines
- Humans
- Immunologic Deficiency Syndromes
- Immunotherapy
- Male
- Meningitis, Meningococcal