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Article

Novel Mutations Causing C5 Deficiency in Three North-African Families.

Journal of clinical immunology - 1 May 2016

Colobran Roger, Franco-Jarava Clara, Martín-Nalda Andrea, Baena Neus, Gabau Elisabeth, Padilla Natàlia, de la Cruz Xavier, Pujol-Borrell Ricardo, Comas David, Soler-Palacín Pere, Hernández-González Manuel

Abstract excerpt

The complement system plays a central role in defense to encapsulated bacteria through opsonization and membrane attack complex (MAC) dependent lysis. The three activation pathways (classical, lectin, and alternative) converge in the cleavage of C5, which initiates MAC formation and target lysis. C5 deficiency is associated to recurrent infections by Neisseria spp. In the present study, complement deficiency was...

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PMID: 27026170
DOI: 10.1007/s10875-016-0275-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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