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Article

Polymorphisms of the CRP gene inhibit inflammatory response and increase susceptibility to depression: the Health in Men Study.

International journal of epidemiology - 1 Aug 2009

Almeida Osvaldo P, Norman Paul E, Allcock Richard, van Bockxmeer Frank, Hankey Graeme J, Jamrozik Konrad, Flicker Leon

Abstract excerpt

BACKGROUND: Depression has been associated with chronic changes in the serum concentration of C-reactive protein (CRP) in observational studies, but it is unclear if this association is causal or is due to confounding and bias. Genetic studies are less subject to this type of error and offer an opportunity to investigate if CRP is causally linked to depression, particularly because known polymorphisms of the CRP...

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Identifiers

PMID: 19433520
DOI: 10.1093/ije/dyp199
PMCID: PMC2720397

Genes

CRP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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