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Article

Expression of TGF-β isoforms, TGF-β receptors, and SMAD molecules at different stages of human glioma

1 Jan 2000

Abstract excerpt

Human gliomas express TGF-beta but, so far the expression of downstream mediators has been investigated in only a few cell lines. We have examined tissue specimens of 23 gliomas: 3 astrocytomas grade II (AST), 8 anaplastic astrocytomas grade III (AAST), and 12 glioblastoma multiforme grade IV (GBM). We analyzed the mRNA expression of TGF-beta1, TGF-beta2, TGF-beta3, the TGF-beta receptors type I (TbetaR-I) and...

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PMID: 10861501
DOI: 10.1002/1097-0215(20000520)89:3<251::aid-ijc7>3.0.co;2-5

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