Article
Telomere length in Hutchinson-Gilford progeria syndrome.
Mechanisms of ageing and development - 1 Jun 2009
Decker Michelle L, Chavez Elizabeth, Vulto Irma, Lansdorp Peter M
Abstract excerpt
Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare premature aging disorder caused by mutations in the gene LMNA, which encodes the nuclear matrix protein lamin A. Previous research has shown that the average telomere length in fibroblasts from HGPS patients is shorter than in age-matched controls. How mutations in lamin A lead to shortened telomere lengths is not known nor is the contribution of individual...
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