Differences in the ability to generate type 1 T helper cells need not determine differences in the ability to resist Mycobacterium tuberculosis infection among mouse strains.

Abstract excerpt

BACKGROUND: C57BL/6 (B6) and BALB/c mice are considerably more resistant to infection with Mycobacterium tuberculosis than DBA/2 mice. METHODS: To determine whether the difference in resistance is because DBA/2 mice generate a type 1 T helper (Th1) immune response of lower magnitude, the Th1 response to airborne infection of mice of all 3 strains was measured in terms of the number of interferon...

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