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Article

Pancreatic beta cells and islets take up thiamin by a regulated carrier-mediated process: studies using mice and human pancreatic preparations.

American journal of physiology. Gastrointestinal and liver physiology - 1 Jul 2009

Mee Lisa, Nabokina Svetlana M, Sekar V Thillai, Subramanian Veedamali S, Maedler Kathrin, Said Hamid M

Abstract excerpt

Thiamin is essential for the normal function of the endocrine pancreas, but very little is known about uptake mechanism(s) and regulation by beta cells. We addressed these issues using mouse-derived pancreatic beta-TC-6 cells, and freshly isolated primary mouse and human pancreatic islets. Results showed that thiamin uptake by beta-TC-6 cells involves a pH (but not Na+)-dependent carrier-mediated process that is...

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Identifiers

PMID: 19423748
DOI: 10.1152/ajpgi.00092.2009
PMCID: PMC2711754

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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