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<i>Pseudomonas aeruginosa</i> Microevolution during Cystic Fibrosis Lung Infection Establishes Clones with Adapted Virulence

7 May 2009

Abstract excerpt

RATIONALE: During long-term lung infection in patients with cystic fibrosis (CF), Pseudomonas aeruginosa strains develop mutations leading to clonal expansion. This microevolution is believed to be correlated with a reduced virulence. OBJECTIVES: We tested this hypothesis in models of lung infection, using mice with different genetic backgrounds. METHODS: From infected airways of six patients with CF, 25 P....

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PMID: 19423715
DOI: 10.1164/rccm.200812-1943oc

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