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Comparative genomics and biological characterization of sequential Pseudomonas aeruginosa isolates from persistent airways infection

1 Dec 2015

Abstract excerpt

BACKGROUND: Pseudomonas aeruginosa establishes life-long chronic airway infections in cystic fibrosis (CF) patients. As the disease progresses, P. aeruginosa pathoadaptive variants are distinguished from the initially acquired strain. However, the genetic basis and the biology of host-bacteria interactions leading to a persistent lifestyle of P. aeruginosa are not understood. As a model system to study long term...

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PMID: 26714629
DOI: 10.1186/s12864-015-2276-8

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